Sporadic Parkinsonism
نویسنده
چکیده
Background Differential diagnosis of parkinsonian sindrome is a major challenge in movement disorders because at the onset there is an overlapping of signs and syntoms. From a neuropathological point of view, parkinsonism may be related to a degeneration of the nigrostriatal pathway or the neurodegenerative process may be more widespread [1,2]. In the early course of the a disease presenting with parkinsonian symptoms, differentiation between these disorders may be difficult, [3,4], but the clinical diagnostic criteria become more applicable during later stages. Motor symptoms (bradikynesia, tremor at rest, rigidity) may be asoociated to cognitive disfunction. Sporadic parkinsonism may be distinguished in:) Multiple system atrophy (MSA), Progressive supranuclear palsy (PSP), Corticobasal degeneration, and Lewy body dementia [3,5,6].
منابع مشابه
The nigrostriatal pathway in Creutzfeldt-Jakob disease.
Parkinsonism, chorea, and dystonia are well-known clinical manifestations of Creutzfeldt-Jakob disease (CJD), but lesions of the nigrostriatal pathway have never been thoroughly studied. We performed a detailed neuropathologic study of the nigrostriatal pathway in 15 sporadic CJD and 2 variant CJD cases that included clinical correlations and assessment of neuron subtype loss, distribution of p...
متن کاملHow genetics research in Parkinson's disease is enhancing understanding of the common idiopathic forms of the disease.
PURPOSE OF REVIEW Rapid progress in genetics has meant that there are now five genes identified for 'Parkinson's disease'. The detailed phenotypes vary, but generally the dominant genes cause a Lewy body disease spectrum whereas recessive genes cause a milder parkinsonism with variable inclusion body pathology. The subject of this review is to highlight these discoveries and to discuss their re...
متن کاملGenome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy.
Genetic analysis of Parkinson disease (PD) has identified several genes whose mutation causes inherited parkinsonism, as well as risk loci for sporadic PD. PTEN-induced kinase 1 (PINK1) and parkin, linked to autosomal recessive PD, act in a common genetic pathway regulating the autophagic degradation of mitochondria, termed mitophagy. We undertook a genome-wide RNAi screen as an unbiased approa...
متن کاملParkinsonism among Gaucher disease carriers.
An association between Gaucher disease and Parkinson disease has been demonstrated by the concurrence of Gaucher disease and parkinsonism in rare patients and the identification of glucocerebrosidase mutations in probands with sporadic Parkinson disease. Using a different and complementary approach, we describe 10 unrelated families of subjects with Gaucher disease where obligate or confirmed c...
متن کاملDifferential Diagnosis of Parkinsonism
Parkinsonism refers to a clinical syndrome characterized by a variable combination of tremor, bradykinesia or akinesia, rigidity, and postural instability. In general, two of these four features must be present to make a diagnosis of parkinsonism. However, the situation is complicated by rare cases of pure akinesia in the absence of tremor and rigidity that have the classic pathology of Parkins...
متن کامل